Reduction of Thyroid Hormone Levels by Glucuronosyltransferase Inducers
نویسندگان
چکیده
منابع مشابه
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation.
Treatment of rats with the microsomal enzyme inducers pregnenolone-16alpha-carbonitrile (PCN), 3-methylcholanthrene (3-MC), and Aroclor 1254 [PCB (polychlorinated biphenyl)] has been shown to decrease circulating levels of thyroid hormones as well as increase microsomal glucuronidation of thyroxine (T(4)). In addition, PCN increases triiodothyronine (T(3)) uridine diphosphate glucuronosyltransf...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1993
ISSN: 0916-1139
DOI: 10.2133/dmpk.8.supplement_621